LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Human papillomavirus type 18 E5 oncoprotein cooperates with E6 and E7 in promoting cell viability and invasion and in modulating the cellular redox state

Hochmann Valls, Jimena Paola; Parietti Pintos, Felipe Álvaro; Martínez Cazarre, Jennyfer; López Royes, Ana Clara; Carreño Sastre, Mara; Quijano Herrera, Celia Lía; Boccardo, Enrique; Sichero, Laura; Möller Rodríguez, Matías Nicolás; Mirazo Villar, Santiago; Arbiza Rodonz, Juan Ramón.

Mem. Inst. Oswaldo Cruz; 115 (), 2020

BACKGROUND High-risk human papillomaviruses (HR-HPVs) are the etiological agents of cervical cancer. Among them, types 16 and 18 are the most prevalent worldwide. The HPV genome encodes three oncoproteins (E5, E6, and E7) that possess a high transformation potential in culture cells when transduced simu...

Línea Celular Tumoral/virología, Proliferación Celular, Supervivencia Celular, Transformación Celular Viral/genética, Proteínas de Unión al ADN/metabolismo, Regulación Neoplásica de la Expresión Génica, Papillomavirus Humano 18/metabolismo, Proteínas Oncogénicas Virales/metabolismo, Oxidación-Reducción

Fulltext

Human polyomaviruses and cancer: an overview

Clinics; 73 (supl.1), 2018

The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the capacity of mediating cell transformation and tumo...