Human papillomavirus type 18 E5 oncoprotein cooperates with E6 and E7 in promoting cell viability and invasion and in modulating the cellular redox state
Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND High-risk human papillomaviruses (HR-HPVs) are the etiological agents of cervical cancer. Among them, types 16 and 18 are the most prevalent worldwide. The HPV genome encodes three oncoproteins (E5, E6, and E7) that possess a high transformation potential in culture cells when transduced simu...
Línea Celular Tumoral/virología, Proliferación Celular, Supervivencia Celular, Transformación Celular Viral/genética, Proteínas de Unión al ADN/metabolismo, Regulación Neoplásica de la Expresión Génica, Papillomavirus Humano 18/metabolismo, Proteínas Oncogénicas Virales/metabolismo, Oxidación-Reducción