Results: 5

Is bipolar disorder associated with premature aging?

Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status

Abstract Background Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is in...

Cell therapy in the treatment of bipolar mania in an animal model: a proof of concept study

Abstract Introduction The rationale of mesenchymal stem cells (MSCs) as a novel therapeutic approach in certain neurodegenerative diseases is based on their ability to promote neurogenesis. Hippocampal atrophy has been related to bipolar disorder (BD) in preclinical, imaging and postmortem studies. The...

Importancia de alteracoes do ciclo intracelular do fosfoinositol na fisiopatologia do disturbio bipolar: estudos preliminares em modelos plaquetarios
Importance of intracellular cycle alterations of phosphatidylinositols in bipolar disorder physiopathology: blood platelet models: preliminary studies

O ciclo intracelular do fosfoinositol (PI) e uma via de segundos mensageiros que pode estar desregulada em pacientes com disturbio bipolar. Essa hipotese tem sido investigada em alguns laboratorios com o uso de modelos plaquetarios, celulas sanguineas ou tecidos cerebrais de autopsia. Recentemente novos ...

Comentarios sobre serotonina y enfermedad bipolar
Comments about serotonine and bipolar disease

De la revisión de algunos estudios se pretende elucubrar respecto de las relaciones entre serotonina y enfermedad maníaco depresiva: interesante resulta la llamada hipótesis permisiva, que sugiere que es necesario, pero no suficiente, el déficit de este neurotransmisor. Al respecto se sabe que los pr...