Trametinib and dabrafenib induced rhabdomyolysis, renal failure, and visual loss. Report of one case
Rev. méd. Chile; 148 (11), 2020
ABSTRACT MEK- and BRAF-inhibitors trametinib and dabrafenib are successfully used for BRAF-mutated, metastasizing melanoma, but these compounds may induce side effects. We report a 50 years old female with BRAF-mutated metastasizing melanoma who received trametinib (2 mg/d) and dabrafenib (200 mg/d) afte...
Insuficiencia Renal, Rabdomiólisis, Neoplasias Cutáneas, Protocolos de Quimioterapia Combinada Antineoplásica, Imidazoles, Mutación, Oximas, Proteínas Proto-Oncogénicas B-raf/genética, Piridonas/efectos adversos, Pirimidinonas, Rabdomiólisis/inducido químicamente, Neoplasias Cutáneas/tratamiento farmacológico, Trastornos de la Visión/inducido químicamente