LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Hypoxia inducible factor-1 (HIF-1α) reduced inflammation in spinal cord injury via miR-380-3p/ NLRP3 by Circ 0001723

Li, Xigong; Lou, Xianfeng; Xu, Sanzhong; Du, Junhua; Wu, Junsong.

Biol. Res; 53 (), 2020

BACKGROUND: Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal cord injury (SCI) to uncover the molecular mechanisms of anti-inflammation. RESULTS: HIF-1α was reduced in SCI model rats and HIF-1α activa...

Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo, Inflamación/metabolismo, MicroARNs/genética, Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo, ARN Circular/genética, Traumatismos de la Médula Espinal/metabolismo, Citocinas/sangre, Regulación de la Expresión Génica, Ratas Sprague-Dawley

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Protective effects of melatonin on spinal cord injury

Spinal cord injury causes neuron nerve fiber loss. The aim of this study was to investigate the neuroprotective, inflammatory and angiogenetic effects of melatonin on rat spinal cord injury (SCI). For spinal cord injury, a standard weight reduction method was used that caused moderate severity of injury ...