Abstract The aim of this study was to evaluate the effectiveness of 3 different fluences of low-level laser therapy (LLLT) in intermediate period of spinal cord repair using an experimental model in rats. Thirty two rats were randomly divided into four experimental groups: Control Group (CG); Laser treat...
OBJECTIVE: To evaluate the effects of interleukin-6 (IL-6) and erythropoietin (EPO) in experimental acute spinal cord injury (SCI) in rats. METHODS: Using standardized equipment, namely, a New York University (NYU) Impactor, a SCI was produced in 50 Wistar rats using a 10-g weight drop from a 12.5-mm he...
Modelos Animales de Enfermedad,
Eritropoyetina/farmacología,
Eritropoyetina/uso terapéutico,
Potenciales Evocados Motores/efectos de los fármacos,
Interleucina-6/farmacología,
Interleucina-6/uso terapéutico,
Fármacos Neuroprotectores/farmacología,
Ratas Wistar,
Recuperación de la Función/efectos de los fármacos,
Traumatismos de la Médula Espinal/tratamiento farmacológico,
Traumatismos de la Médula Espinal/patología
SUMMARY: In spinal cord injury, radical treatment is still a persistent hope for patients and clinicians. Our study aimed to determine the different histological changes in central, cranial and caudal sites of compressed spinal cord as a result of neuroectodermal stem cells (NESCs) transplantation in rat...
SUMMARY: Traumatic injury to the spinal cord results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules that...
Reishi/química,
Fármacos Neuroprotectores/administración & dosificación,
Traumatismos de la Médula Espinal/tratamiento farmacológico,
Ratas Sprague-Dawley,
Traumatismos de la Médula Espinal/patología,
Inmunohistoquímica,
Etiquetado Corte-Fin in Situ,
Malondialdehído/análisis,
Glutatión/análisis,
Peroxidasa/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos
This study evaluated the effect of microglia transplantation on neurological functional recovery in rats subjected to traumatic spinal cord injury (SCI). The rat model of SCI was established using a weight drop device. Forty SCI rats were randomly divided into the microglia group and the saline group. Th...
OBJECTIVES: To evaluate the effects of combined treatment with granulocyte colony-stimulating factor (G-CSF) and methylprednisolone in rats subjected to experimental spinal cord injury. METHODS: Forty Wistar rats received a moderate spinal cord injury and were divided into four groups: control (no treat...
Modelos Animales de Enfermedad,
Combinación de Medicamentos,
Factor Estimulante de Colonias de Granulocitos/farmacocinética,
Metilprednisolona/farmacocinética,
Fármacos Neuroprotectores/farmacocinética,
Distribución Aleatoria,
Ratas Wistar,
Recuperación de la Función/efectos de los fármacos,
Valores de Referencia,
Reproducibilidad de los Resultados,
Traumatismos de la Médula Espinal/tratamiento farmacológico,
Traumatismos de la Médula Espinal/patología,
Traumatismos de la Médula Espinal/rehabilitación,
Factores de Tiempo,
Resultado del Tratamiento
OBJECTIVE: To standardize a spinal cord lesion mouse model. METHODS: Thirty BALB/c mice were divided into five groups: four experimental groups and one control group (sham). The experimental groups were subjected to spinal cord lesion by a weight drop from different heights after laminectomy whereas the...
Modelos Animales de Enfermedad,
Hiperemia,
Locomoción/fisiología,
Ratones Endogámicos BALB C,
Actividad Motora/fisiología,
Reproducibilidad de los Resultados,
Traumatismos de la Médula Espinal/etiología,
Traumatismos de la Médula Espinal/patología,
Traumatismos de la Médula Espinal/fisiopatología,
Factores de Tiempo,
Índices de Gravedad del Trauma
Abstract Purpose: To investigate the efficacy of allogeneic mesenchymal stem-cells and autologous mononuclear cells to promote sensorimotor recovery and tissue rescue. Methods: Female rabbits were submitted to the epidural balloon inflation method and the intravenous cells administrations were made a...
Trasplante de Médula Ósea/métodos,
Modelos Animales de Enfermedad,
Leucocitos Mononucleares/trasplante,
Trasplante de Células Madre Mesenquimatosas/métodos,
Vías Nerviosas,
Recuperación de la Función,
Traumatismos de la Médula Espinal/patología,
Traumatismos de la Médula Espinal/fisiopatología,
Traumatismos de la Médula Espinal/cirugía,
Factores de Tiempo,
Tomografía Computarizada por Rayos X,
Trasplante Autólogo,
Trasplante Homólogo
Objetivo: Criar e testar as propriedades psicométricas de um instrumento específico para quantificação da qualidade de vida de indivíduos com lesão da medula espinal. Método: A partir dos métodos de consenso existentes, foi escolhida a técnica Delphi para criação do questionário e o SF-36 com...
