LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection

Cascabulho, Cynthia M; Meuser-Batista, Marcelo; Moura, Kelly Cristina G de; Pinto, Maria do Carmo; Duque, Thabata Lopes Alberto; Demarque, Kelly C; Guimarães, Ana Carolina Ramos; Manso, Pedro Paulo de Abreu; Pelajo-Machado, Marcelo; Oliveira, Gabriel M; Castro, Solange L De; Menna-Barreto, Rubem FS.

Mem. Inst. Oswaldo Cruz; 115 (), 2020

BACKGROUND Chagas disease, which is caused by the protozoan Trypanosoma cruzi, is endemic to Latin America and mainly affects low-income populations. Chemotherapy is based on two nitrocompounds, but their reduced efficacy encourages the continuous search for alternative drugs. Our group has characterise...

Enfermedad Aguda, Antiinflamatorios, Enfermedad de Chagas/tratamiento farmacológico, Modelos Animales de Enfermedad, Electrocardiografía, Naftoquinonas/química, Naftoquinonas/uso terapéutico, Nitroimidazoles/química, Nitroimidazoles/uso terapéutico, Parasitemia/tratamiento farmacológico, Factores de Tiempo, Tripanocidas/química, Tripanocidas/uso terapéutico

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From Medicinal Chemistry to Human Health: Current Approaches to Drug Discovery for Cancer and Neglected Tropical Diseases

ABSTRACT Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This evolving paradigm, which has its roots attached to the recent advances in medicinal chemistry, molecular and structural biology, has unprec...