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Melatonin decreases cocaine-induced locomotor activity in pinealectomized rats

Barbosa-Méndez, Susana; Salazar-Juárez, Alberto.
Braz. J. Psychiatry (São Paulo, 1999, Impr.); 42 (3), 2020
Objective: Several studies have shown that the time of day regulates the reinforcing effects of cocaine. Additionally, melatonin and its MT1 and MT2 receptors have been found to participate in modulation of the reinforcing effects of such addictive drugs as cocaine. Loss of the diurnal variation in cocai...
Depresores del Sistema Nervioso Central/farmacología, Ritmo Circadiano, Trastornos Relacionados con Cocaína/tratamiento farmacológico, Ensayo de Inmunoadsorción Enzimática, Locomoción/efectos de los fármacos, Melatonina/farmacología, Pinealectomía, Distribución Aleatoria, Ratas Wistar, Reproducibilidad de los Resultados, Factores de Tiempo, Resultado del Tratamiento, Triptaminas/farmacología
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Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models

SOUSA-NETO, BENEDITO P; GOMES, BRUNO S; CUNHA, FRANCISCO V M; ARCANJO, DANIEL D R; GUTIERREZ, STANLEY J C; SOUZA, MARIA F V; ALMEIDA, FERNANDA R C; OLIVEIRA, FRANCISCO A.
An. acad. bras. ciênc; 90 (1), 2018
ABSTRACT The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. ...
Antiinflamatorios/farmacología, Antiinflamatorios/toxicidad, Carragenina, Modelos Animales de Enfermedad, Edema/inducido químicamente, Edema/tratamiento farmacológico, Miembro Posterior, Mediadores de Inflamación, Péptidos/efectos de los fármacos, Ratas Wistar, Salicilatos/farmacología, Salicilatos/toxicidad, Factores de Tiempo, Triptaminas/farmacología, Triptaminas/toxicidad
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