Triterpenes are very important secondary metabolites with wide structural diversity and
significant role in pharmacy and medicine.
In the present research, a comparative study of
pharamacological activities of the triterpene fractions obtained from several pla...
Santos, Andreia Fuentes;
Souza, Marília Moraes Queiroz;
Pauli, Karoline Bach;
da Silva, Gustavo Ratti;
Marques, Midia Wolff;
Auth, Pablo Alvarez;
Bortolucci, Wanessa de Campos;
Gazim, Zilda Cristiani;
Linde, Giani Andrea;
Colauto, Nelson Barros;
Lovato, Evellyn Claudia Wietzikoski;
Lívero, Francislaine Aparecida dos Reis.
Bacopa monnieri(L.) Wettst. (Plantaginaceae), also known as Brahmi, has been used to improve cognitive processes and intellectual functions that are related to the preservation of memory. The objective of this research is to review the ethnobotanical applications, phytochemical composition, toxicity and...
Bacopa/química,
Extractos Vegetales/administración & dosificación,
Enfermedades del Sistema Nervioso Central/tratamiento farmacológico,
Enfermedad de Alzheimer/tratamiento farmacológico,
Enfermedad de Parkinson/tratamiento farmacológico,
Epilepsia/tratamiento farmacológico,
Esquizofrenia/tratamiento farmacológico,
Extractos Vegetales/química,
Sistema Nervioso Central/efectos de los fármacos,
Cognición/efectos de los fármacos,
Saponinas/análisis,
Triterpenos/análisis,
Fitoquímicos
Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three mai...
Platycodin D (PD) is a major constituent of Platycodon grandiflorum and has multiple functions in disease control. This study focused on the function of PD in bladder cancer cell behaviors and the molecules involved. First, we administered PD to the bladder cancer cell lines T24 and 5637 and the human ur...
Apoptosis,
Línea Celular Tumoral,
Proliferación Celular,
Regulación Neoplásica de la Expresión Génica,
MicroARNs,
Fosfatidilinositol 3-Quinasas/metabolismo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Saponinas,
Triterpenos,
Neoplasias de la Vejiga Urinaria/tratamiento farmacológico,
Neoplasias de la Vejiga Urinaria/genética
Yang, Dong-lin;
Zhang, Ya-jun;
He, Liu-jun;
Hu, Chun-sheng;
Gao, Li-xia;
Huang, Jiu-hong;
Tang, Yan;
Luo, Jie;
Tang, Dian-yong;
Chen, Zhong-zhu.
BACKGROUND: Demethylzeylasteral (T-96) is a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF) that has been reported to exhibit anti-neoplastic effects against several types of cancer cells. However, the potential anti-tumour effects of T-96 against human P...
Abstract Thevetia peruviana is an ornamental shrub grown-up in many tropical region of the world. This plant produces secondary metabolites with biological properties of interest for the pharmaceutical industry. The objective was to determine the secondary metabolites profile of callus and cell suspensio...
Células Cultivadas,
Fitoquímicos/biosíntesis,
Cromatografía Líquida de Alta Presión,
Thevetia/química,
Thevetia/citología,
Técnicas de Cultivo,
Fitoquímicos/análisis,
Triterpenos,
Flavonoides,
Antioxidantes,
Anticarcinógenos
Cavalcante, Géssica Soares;
Morais, Selene Maia de;
André, Weibson Paz Pinheiro;
Araújo-Filho, José Vilemar de;
Muniz, Celli Rodrigues;
Rocha, Letícia Oliveira da;
Ribeiro, Wesley Lyeverton Correia;
Rodrigues, Ana Livya Moreira;
Oliveira, Lorena Mayana Beserra de;
Bevilaqua, Claudia Maria Leal;
Ramos, Márcio Viana.
Abstract This study aimed to evaluate the anthelmintic and ultrastructural effects of Calotropis procera latex on Haemonchus contortus. C. procera latex was twice centrifuged at 10,000×g and dialyzed to obtain a fraction rich in proteins, named LP (latex protein), and at 3,000 rpm to obtain a fraction r...
Haemonchus/efectos de los fármacos,
Calotropis/química,
Látex/química,
Antihelmínticos/farmacología,
Haemonchus/ultraestructura,
Técnicas In Vitro,
Cromatografía Líquida de Alta Presión,
Enfermedades de las Ovejas/parasitología,
Resistencia a Medicamentos,
Ovinos/parasitología,
Hemoncosis/veterinaria,
Haemonchus/aislamiento & purificación,
Látex/aislamiento & purificación,
Haemonchus/fisiología,
Microscopía Electrónica de Rastreo,
Brasil,
Fenoles/química,
Taninos/química,
Antocianinas/química,
Fitosteroles/química,
Triterpenos/química,
Saponinas/química,
Alcaloides/química,
Cardenólidos/química
Manilkara zapota (Sapotaceae), commonly known as Sapodilla, is widely known for its delicious fruit. Various parts of this plant are also used in folk medicine to treat a number of conditions including fever, pain, diarrhoea, dysentery, haemorrhage and ulcers. Scientific studies have demonstrated analges...
Manilkara/química,
Sapotaceae/química,
Medicina Tradicional,
Compuestos Fenólicos/análisis,
Extractos Vegetales/farmacología,
Fenoles/aislamiento & purificación,
Fenoles/farmacología,
Carotenoides/aislamiento & purificación,
Carotenoides/farmacología,
Triterpenos/aislamiento & purificación,
Triterpenos/farmacología,
Saponinas/aislamiento & purificación,
Saponinas/farmacología,
Esteroles/aislamiento & purificación,
Esteroles/farmacología
Tillandsia L. genus comprises 649 species, with different uses at different times. T. usneoides L. uses are reported since the late- archaic and pre-Columbian cultures. In XIX-XX centuries, T. usneoides was used in some manufactured products, as polish and packing fruit. Tillandsia has a favorable reputa...
Himatanthus drasticus (Mart.) Plumel belongs to the Apocynaceae family and the latex from its trunk bark (Hd) is known as "janaguba milk". This latex is widely used in Northeast Brazil, mainly in the Cariri region, for its gastroprotective, anti-inflammatory, and antitumor properties. The objective of th...
Analgésicos/uso terapéutico,
Antiinflamatorios/uso terapéutico,
Apocynaceae/química,
Biomarcadores/sangre,
Modelos Animales de Enfermedad,
Edema/tratamiento farmacológico,
Inmunohistoquímica,
Inflamación/tratamiento farmacológico,
Ratas Wistar,
Triterpenos/aislamiento & purificación,
Triterpenos/uso terapéutico
