LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus

de-Almeida, S C X; da-Silva, Â C F; Sousa, N R T; Amorim, I H F; Leite, B G; Neves, K R T; Costa, J G M; Felipe, C F B; de-Barros Viana, G S.

Braz. j. med. biol. res; 52 (5), 2019

Himatanthus drasticus (Mart.) Plumel belongs to the Apocynaceae family and the latex from its trunk bark (Hd) is known as "janaguba milk". This latex is widely used in Northeast Brazil, mainly in the Cariri region, for its gastroprotective, anti-inflammatory, and antitumor properties. The objective of th...

Analgésicos/uso terapéutico, Antiinflamatorios/uso terapéutico, Apocynaceae/química, Biomarcadores/sangre, Modelos Animales de Enfermedad, Edema/tratamiento farmacológico, Inmunohistoquímica, Inflamación/tratamiento farmacológico, Ratas Wistar, Triterpenos/aislamiento & purificación, Triterpenos/uso terapéutico

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Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity

Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the...