Purpose: Over-activation of nuclear factor kappa B (NF-κB) was proven to be involved in the pathogenesis of preeclampsia. However, its regulation mechanism is not clear yet. This paper explored the role of WD repeat domain 5 (WDR5) in the development of late-onset preeclampsia and its relationship with ...
SUMMARY: Trophoblasts perform different functions depending on their location. This study aimed to obtain structural clues about the functions of villous and extravillous trophoblasts by using light and electron microscopy. Term placenta samples were obtained from 10 healthy pregnant women following cesa...
BACKGROUND: Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). METHODS: High-throughput sequencing was used to collect the plasma circRNAs expression pr...
Peng, Pingping;
Song, Huamei;
Xie, Chenghong;
Zheng, Wenfei;
Ma, Huigai;
Xin, Dandan;
Zhan, Jingqiong;
Yuan, Xiaoqing;
Chen, Aihua;
Tao, Jing;
Qin, Jufang.
OBJECTIVE: This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE). METHODS: Expression levels of miR-146a-5p and Wnt2 in preeclamptic and normal placentae were quantified. Trophoblast cells (HTR-8) were separately transfected with ...
Preeclampsia (PE) is a complex pregnancy syndrome. Convincing evidence indicates that long non-coding RNAs (lncRNAs) are involved in the pathogenesis of PE. This research mainly investigated the mechanism of family with sequence similarity 99 member A (FAM99A) in PE. The expressions of FAM99A, miR-134-5p...
La placenta es un anexo embrionario de los mamÃferos que tiene por función principal el intercambio de nutrientes y gases y proteger al concepto de un potencial daño inmune provocado por diferencias alogénicas en los Complejos Principales de Histocompatibilidad paternos. Se han descrito diversas prot...
La Enfermedad Trofoblástica Gestacional (ETG) es una patologÃa de la primera mitad del embarazo caracterizada por una degeneración hidrópica de las vellosidades coriales que abarca la placenta y el resto del complejo ovular; es generalmente benigna pero puede malignizarse y distribuirse hacia otros t...
Un embarazo exitoso requiere de una serie de interacciones mediadas por factores hormonales, moleculares y fenómenos de inmunomodulación. Una de estas interacciones es la que ocurre entre el endometrio y el blastocito, previo y durante el proceso de implantación. El objetivo de esta revisión bibliogr...
Evidence from the literature shows that well-controlled glucose levels during pregnancy are usually associated with normal placental morphology. The aim of this study was to identify the lacental changes attributed to maternal hyperglycemia. A total of 20 placentae were selected for study from a tertiary...
O feto é um ser alogênico de sucesso. O feto é um aloenxerto natural bem tolerado pelo
organismo materno. Vários fatores contribuem para a tolerância materna ao feto: 1. O útero
é um local do corpo imunologicamente privilegiado, protegido por uma barreira tecidual
não imunogênica; 2. A promoÃ...
