Pacientes com COVID-19 podem apresentar trombocitopenia grave.
Esse achado tem importante impacto no aumento de desfechos negativos
e mortalidade, representando um importante fator prognóstico da
doença. Vários mecanismos etiopatogênicos foram descritos, sendo a
trombocitopenia imune um dos fatores m...
SUMMARY OBJECTIVE Thrombopoietin (THPO) is well-known as a megakaryocyte growth and development factor (MGDF) involved in megakaryocyte proliferation and maturation. To explore the biological effects of THPO in gastric adenocarcinoma, we conducted this study. Methods: By accessing the TCGA database, th...
ABSTRACT Background: Human aplastic anemia is a hematologic disease characterized by low peripheral blood cell counts associated with reduced numbers of hematopoietic stem and progenitor cells and a hypocellular bone marrow. Thrombopoietin (THPO) regulates megakaryocytes, but it also stimulates hematopo...