Results: 3

Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux

Biol. Res; 56 (), 2023
BACKGROUND: Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and decreased strength and muscle function, a syndrome known as sarcopenia. Recently, our ...

Interleukin-6 contributes to myocardial damage in pregnant rats with reduced uterine perfusion pressure

Braz. j. med. biol. res; 51 (8), 2018
Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusi...

Influência do pré-condicionamento isquêmico na proteçäo miocárdica em revascularizaçäo do miocárdio com pinçamento intermitente da aorta
Influence of the ischemic preconditioning in the myocardial protection in myocardial revascularization with intermittent aortic cross-clamping

Objetivo: Este estudo testa a hipótese de que curtos períodos de isquemia podem aumentar a proteçäo obtida pelo pinçamento intermitente da aorta. Métodos: No grupo controle (18), a operaçäo foi realizada com hipotermia sistêmica a 32 ºC com pinçamento intermitente da aorta e uso de circulaçä...