Núñez, Marvin J;
Paz-González, Alma D;
Vásquez-Jiménez, Lenci K;
Castillo, Ulises G;
Moo-Puc, Rosa;
Chan-Bacab, Jesús M;
Aguilera-Arreola, Guadalupe;
Catalán-Gonzalez, Lucero;
Quintana-Gómez, Alexis Uriel;
Castañeda-Sánchez, Jorge Ismael;
Luna-Herrera, Julieta;
Rivera, Gildardo.
Currently, in developing countries, parasitic and bacterial diseases as amebiasis, giardiasis, trichonomiasis, leishmaniasis, trypanosomiasis, tuberculosis, and nocardiasis are a public health problem. The pharmacological treatment for these diseases is not completely effective and c...
Flora,
Extractos Vegetales/farmacología,
Antiparasitarios/farmacología,
Antibacterianos/farmacología,
Parásitos/efectos de los fármacos,
Técnicas In Vitro,
El Salvador,
Bacterias/efectos de los fármacos,
Mycobacterium tuberculosis,
Trypanosoma cruzi/efectos de los fármacos,
Extractos Vegetales/química,
Antiparasitarios/química,
Antibacterianos/química,
Pruebas de Sensibilidad Microbiana,
Flavonoides/análisis,
Monoterpenos/análisis,
Amoeba/efectos de los fármacos,
Cromatografía Líquida de Alta Presión
Abstract INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new an...
ABSTRACT The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benz...
Electroforesis en Gel Bidimensional,
Espectrometría de Masas,
Estrés Oxidativo,
Piperidonas/farmacología,
Extractos Vegetales/farmacología,
Proteínas/análisis,
Proteómica,
Valores de Referencia,
Reproducibilidad de los Resultados,
Tripanocidas/farmacología,
Trypanosoma cruzi/química,
Trypanosoma cruzi/efectos de los fármacos,
Trypanosoma cruzi/metabolismo
BACKGROUND The current chemotherapy for Chagas disease is based on monopharmacology with low efficacy and drug tolerance. Polypharmacology is one of the strategies to overcome these limitations. OBJECTIVES Study the anti-Trypanosoma cruzi activity of associations of benznidazole (Bnz) with three new syn...
Abstract INTRODUCTION: Approximately seven to eight million people worldwide have Chagas disease. In Brazil, benznidazole is the most commonly used active drug against Trypanosoma cruzi; however, its efficacy is limited, and side effects are frequent. Recent studies suggest that amiodarone may be benefi...
Amiodarona/administración & dosificación,
Amiodarona/farmacología,
Relación Dosis-Respuesta a Droga,
Combinación de Medicamentos,
Ratones,
Nitroimidazoles/administración & dosificación,
Nitroimidazoles/farmacología,
Pruebas de Sensibilidad Parasitaria,
Tripanocidas/administración & dosificación,
Tripanocidas/farmacología,
Trypanosoma cruzi/efectos de los fármacos
Eukaryotic initiation factor 5A (eIF5A) is a conserved protein with an essential role in translation elongation. Using one and two-dimensional western blotting, we showed that the eIF5A protein level was 2-fold lower in benznidazole (BZ)-resistant (BZR and 17LER) Trypanosoma cruzi populations than in the...
Resistencia a Medicamentos/genética,
Expresión Génica,
Nitroimidazoles/farmacología,
Factores de Iniciación de Péptidos/análisis,
Factores de Iniciación de Péptidos/efectos de los fármacos,
Factores de Iniciación de Péptidos/metabolismo,
Proteínas de Unión al ARN/análisis,
Proteínas de Unión al ARN/efectos de los fármacos,
Proteínas de Unión al ARN/metabolismo,
Tripanocidas/farmacología,
Trypanosoma cruzi/efectos de los fármacos,
Trypanosoma cruzi/enzimología,
Trypanosoma cruzi/genética
ESTEVAM, ELISÂNGELA B B;
DEUS, ISABELLA P B DE;
SILVA, VANESSA P DA;
SILVA, ELIZABETH A J DA;
ALVES, CASSIA C F;
ALVES, JOSÉ MILTON;
CAZAL, CRISTIANE M;
MAGALHÃES, LIZANDRA G;
PAGOTTI, MARIANA C;
ESPERANDIM, VIVIANE R;
SOUZA, ALEX F;
MIRANDA, MAYKER L D.
ABSTRACT Leishmaniasis and trypanosomiasis are globally widespread parasitic diseases which have been responsible for high mortality rates. Since drugs available for their treatment are highly hepatotoxic, nephrotoxic and cardiotoxic, adherence to therapy has been affected. Thus, the search for new, more...
Abstract Resistance to benznidazole in certain strains of Trypanosoma cruzi may be caused by the increased production of enzymes that act on the oxidative metabolism, such as mitochondrial tryparedoxin peroxidase which catalyses the reduction of peroxides. This work presents cytotoxicity assays performed...
A doença de Chagas afeta cerca de 6 a 7 millhões de pessoas no mundo, principalmente América Latina. A busca de alternativas terapêuticas para esta enfermidade tem grande relevância para a sociedade, já que as opções atuais são limitadas, sendo disponível apenas o benznidazol (BZD) e nifurtimox...
Preparaciones Farmacéuticas,
Trypanosoma cruzi/efectos de los fármacos,
Nitrofuranos/análisis,
25873/efectos adversos,
Relación Estructura-Actividad,
Técnicas In Vitro/métodos,
Relación Estructura-Actividad Cuantitativa,
Oxidorreductasas,
Química Farmacéutica/métodos,
Nifurtimox/administración & dosificación,
Citotoxicidad Inmunológica
Trypanosoma cruzi/efectos de los fármacos,
Trypanosoma cruzi/patogenicidad,
Tripanocidas,
Nitroimidazoles,
Nitrofuranos,
Dactinomicina,
Alopurinol,
Tripanosomiasis,
Quelantes,
Tripanosomiasis/complicaciones,
Tripanosomiasis/diagnóstico,
Tripanosomiasis/tratamiento farmacológico,
Tripanosomiasis/transmisión
