Abstract The chemical hydroxymethylation of the antimicrobial nitrofurazone leads to the prodrug NFOH, also increases the anti-T. cruzi activities (in vitro and in vivo), as well as showed non-genotoxic (Ames and micronucleus assays). In the present study, we assessed the anti-T. cruzi effect of the NFOH...
A doença de Chagas, causada pelo parasita Trypanosoma cruzi, acomete entre 6 a 8 milhões de pessoas em todo o mundo. Conhecida como tripanossomíase americana, por ter sido considerada endêmica apenas na América Latina, esta doença, se espalhou para outros continentes devido aos movimentos migratór...
Horta, Aline Luciano;
Figueiredo, Vivian Paulino;
Leite, Ana Luisa Junqueira;
Costa, Guilherme de Paula;
Menezes, Ana Paula de Jesus;
Ramos, Camila de Oliveira;
Pedrosa, Tamiles Caroline Fernandes;
Bezerra, Frank Silva;
Vieira, Paula Melo de Abreu;
Talvani, André.
BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve ...
Chagas disease is an endemic zoonosis that can cause chronic medical complications in a third of those
infected, usually decades after infection. It mainly affects the peripheral nervous system of heart, esophagus
and colon. At digestive level, motor dysfunction leads to the development of megaesophagus ...
Abstract INTRODUCTION: Trypanosoma cruzi, the etiologic agent of Chagas disease, is widely distributed in nature, circulating between triatomine bugs and sylvatic mammals, and has large genetic diversity. Both the vector species and the genetic lineages of T. cruzi present a varied geographical distribu...
Vectores Artrópodos/genética,
Vectores Artrópodos/patogenicidad,
Vectores Artrópodos/fisiología,
Sangre/parasitología,
Brasil,
Enfermedad de Chagas/parasitología,
Enfermedad de Chagas/transmisión,
Interacciones Huésped-Parásitos/fisiología,
Intestinos/parasitología,
Ratones,
Reacción en Cadena de la Polimerasa,
Rhodnius/genética,
Rhodnius/patogenicidad,
Rhodnius/fisiología,
Especificidad de la Especie,
Simpatría,
Factores de Tiempo,
Triatoma/genética,
Triatoma/patogenicidad,
Triatoma/fisiología,
Trypanosoma cruzi/genética,
Trypanosoma cruzi/patogenicidad,
Trypanosoma cruzi/fisiología,
Xenodiagnóstico/métodos
Introducción: la infección por Trypanosoma cruzi, conocida como enfermedad de Chagas, es un problema importante de salud pública en países de América Central y Sudamérica.Objetivo: evaluar la actividad de extractos crudos de acetato de etilo de plantas in vitro de 6-8 meses y 10-12 meses de edad, d...
Se presenta el caso de una persona de género masculino, de 38 años de edad, sin antecedentes médicos personales o familiares, originario de Jutiapa, residente de ciudad de Guatemala, con historia de síncope, a la evaluación inicial con Bloqueo de Rama Derecha, el monitoreo electrocardiográfico de H...
Introduction: Four species of triatomines have been reported in Nuevo León, northeast (NE) México, but Triatoma gerstaeckeri has only been recorded from a peridomestic dwelling. Objectives: To assess the natural infection index (NII) of Trypanosoma cruzi in triatomines and the infestation index (II) of...
Insectos Vectores/parasitología,
Triatoma/parasitología,
Trypanosoma cruzi/aislamiento & purificación,
Tejido Adiposo/parasitología,
Enfermedad de Chagas/epidemiología,
Enfermedad de Chagas/transmisión,
Reservorios de Enfermedades,
Corazón/parasitología,
Vivienda,
México,
Músculo Esquelético/parasitología,
Especificidad de Órganos,
Parasitemia/parasitología,
Trypanosoma cruziCrecimiento,
Trypanosoma cruzi/patogenicidad,
Virulencia
Background The American trypanosomiasis is a zoonosis caused by the protozoaTrypanosoma cruzi (T. cruzi). The disease is widely distributed throughout the American continent, affecting a wide range of hosts, including dogs. It is present in the canine population in the State of Yucatan, Mexico. However, ...
