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Intra-tumor genetic heterogeneity in Wilms tumor samples

de Sá Pereira, Bruna M; Azevedo, Rafaela Montalvão de; Aguirre Neto, Joaquim Caetano de; Menezes, Clarice Franco; Rodrigues, Karla Emília; Faria, Paulo A; Camargo, Beatriz de; Maschietto, Mariana.
Rev. Assoc. Med. Bras. (1992, Impr.); 65 (12), 2019
SUMMARY Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms' tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. ...
Biomarcadores de Tumor/análisis, Neoplasias Renales/genética, Neoplasias Renales/patología, Mutación, Pronóstico, Tumor de Wilms/genética, Tumor de Wilms/patología, Brasil, Heterogeneidad Genética
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Analysis of the p53 gene by PCR-SSCP in ten cases of WilmsÆ tumor

Defavery, Ricardo; Lemos, José Alexandre Rodrigues; Kashima, Simone; Bernardes, José Eduardo; Scridelli, Carlos Alberto; Covas, Dimas Tadeu; Tone, Luiz Gonzaga.
Säo Paulo med. j; 118 (2), 2000
CONTEXT: Mutations of the p53 tumor suppressor gene are the most frequent alterations observed in human neoplasias affecting adults. In pediatric oncology, however, they have seldom been identified. WilmsÆ tumor is a renal neoplasia commonly occurring in children and is associated with mutations of the ...
Mutación/genética, Neoplasias Renales/genética, Tumor de Wilms/genética, Genes p53/genética, Reacción en Cadena de la Polimerasa/métodos, Polimorfismo Conformacional Retorcido-Simple, Análisis de Secuencia de ADN
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