LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

A new gene inventory of the ubiquitin and ubiquitin-like conjugation pathways in Giardia intestinalis

BACKGROUND Ubiquitin (Ub) and Ub-like proteins (Ub-L) are critical regulators of complex cellular processes such as the cell cycle, DNA repair, transcription, chromatin remodeling, signal translation, and protein degradation. Giardia intestinalis possesses an experimentally proven Ub-conjugation system;...

The destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma

Bourroul, Guilherme Muniz; Fragoso, Hélio José; Gomes, José Walter Feitosa; Bourroul, Vivian Sati Oba; Oshima, Celina Tizuko Fujiyama; Gomes, Thiago Simão; Saba, Gabriela Tognini; Palma, Rogério Tadeu; Waisberg, Jaques.

Einstein (Säo Paulo); 14 (2), 2016

ABSTRACT Objective To evaluate the destruction complex of beta-catenin by the expression of the proteins beta-catetenin, adenomatous polyposis coli, GSK3β, axin and ubiquitin in colorectal carcinoma and colonic adenoma. Methods Tissue samples from 64 patients with colorectal carcinoma and 53 pat...

Adenoma/metabolismo, Complejo de Señalización de la Axina/metabolismo, Carcinoma/metabolismo, Neoplasias del Colon/metabolismo, Proteínas de Neoplasias/metabolismo, Neoplasias del Recto/metabolismo, Adenoma/patología, Poliposis Adenomatosa del Colon/metabolismo, Proteína Axina/metabolismo, Carcinoma/patología, Neoplasias del Colon/patología, Glucógeno Sintasa Quinasa 3 beta/metabolismo, Inmunohistoquímica, Estudios Longitudinales, Neoplasias del Recto/patología, Estudios Retrospectivos, Ubiquitina/metabolismo, Vía de Señalización Wnt, beta Catenina/metabolismo

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