Results: 9

Establishment of a production process for a novel vaccine candidate against Lawsonia intracellularis

BACKGROUND: Lawsonia intracellularis remains a problem for the swine industry worldwide. Previously, we designed and obtained a vaccine candidate against this pathogen based on the chimeric proteins: OMP1c, OMP2c, and INVASc. These proteins formed inclusion bodies when expressed in E. coli, which induced...

Pathogenic potential of Brucella ovis field isolates with different genotypic profile and protection provided by the vaccine strain B. ovis ΔabcBA against B. ovis field isolates in mice

Pesqui. vet. bras; 40 (2), 2020
Brucella ovis causes economic and reproductive losses in sheep herds. The goal of this study was to characterize infection with B. ovis field isolates in a murine model, and to evaluate protection induced by the candidate vaccine strain B. ovis ΔabcBA in mice challenged with these field isolates. B. ovi...

DNA nanovaccines prepared using LemA antigen protect Golden Syrian hamsters against Leptospira lethal infection

Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND Nanoparticles (NPs) are viable candidates as carriers of exogenous materials into cells via transfection and can be used in the DNA vaccination strategy against leptospirosis. OBJECTIVES We evaluated the efficiency of halloysite clay nanotubes (HNTs) and amine-functionalised multi-walled ca...

Efficacy of leptospiral commercial vaccines on the protection against an autochtonous strain recovered in Brazil

Braz. j. microbiol; 49 (2), 2018
Abstract In swine and bovines, leptospirosis prevention and control is carried out via vaccination of susceptible animals using bacterins. However, the efficiency of leptospirosis vaccines has been questioned. This work aimed to investigate the potency of five leptospirosis vaccines sold commercially in ...

Immune response and biochemistry of calves immunized with rMSP1a ( Anaplasma marginale) using carbon nanotubes as carrier molecules

Abstract Vaccination against Anaplasma marginale has been considered an important control strategy for bovine anaplasmosis. Recently, mice immunized with rMSP1 a linked to carbon nanotubes (MWNT) showed significant immune responses, generating a new possibility for use of an inactivated vaccine. The obj...

Infecciones del tracto urinario, inmunidad y vacunación

Resumen Las infecciones del tracto urinario (ITU) se consideran como una de las principales causas de morbilidad en el mundo, y Escherichia coli uropatogénica (UPEC, por sus siglas en inglés) es el agente causal asociado a estas infecciones. La alta morbilidad generada por las ITU y la limitación de t...

Estudio funcional de la respuesta inmune a vacunas anti neumocóccicas
Evaluation of functional immune response to pneumococcal vaccines

Rev. chil. infectol; 16 (supl. 1), 1999
Los estudios descritos usan fagocitos cultivables, los cuales ayudan a la estandarización de un ensayo de fagocitos que puede medir repetitivamente la respuesta inmune de anticuerpos funcionales. La opsonofagocitosis parece ser un sustituto apropiado de la protección in vivo, ya que muestra una buena c...

Dosagem de níveis de anticorpos contra polissacarídeos capsulares de Streptococcus pneumoniae após vacinaçäo de pacientes HIV positivos com vacina pneumocócica 23-valente

Streptococcus pneumoniae é o agente causal mais comum de pneumonias bacterianas e bacteremias nao micobacterianas em indivíduos infectados pelo HIV, estimando-se que esses pacientes sejam de 100 a 300 vezes mais susceptíveis à doença pneumocóccica invasiva, se comparados a indivíduos nao infectado...