RESUMO Objetivo: Investigar a efetividade da vancomicina contra Gram-positivos com concentração inibitória mínima de 1mg/L em pacientes pediátricos com base na razão entre área sob a curva e concentração inibitória mínima > 400. Métodos: População de 22 pacientes pediátricos (13 menin...
ABSTRACT Objective Analyze the microbiological effectiveness, based on the pharmacokinetics/pharmacodynamics correlation of vancomycin in pediatric patients, and to propose dose adjustment. Methods This is an observational, cross-sectional study, conducted in a pediatric hospital, over a 1-year perio...
Resumen La presente revisión resume la evidencia sobre la monitorización terapéutica de tres antimicrobianos basada en datos regionales: vancomicina, amikacina y voriconazol en la población pediátrica. Estos datos coinciden con la literatura internacional en relación al requerimiento de dosis mayor...
RESUMO Objetivo: Avaliar se a posologia atualmente utilizada de vancomicina para tratamento de infecções bacterianas graves causadas por microrganismos Gram-positivos em pacientes admitidos à unidade de terapia intensiva proporcionam níveis plasmáticos de vale de vancomicina em nível terapêutico,...
Vancomycin (VAN) is the gold standard therapy for Methicillin-resistant Staphylococcus aureus (MRSA) infections such as bacteremia and endocarditis. However, VAN suboptimal dosing for serious infections caused by S. aureus isolates that have elevated minimum inhibitory concentration (MIC), could be assoc...
In recent years, enterococci have emerged as important pathogens. These organisms are now the third most commonly encountered nosocomial bloodstream infection pathogens in many part of the world. Due to increasing frequency with which multi-drug resistant enterococci are isolated from clinical specimens,...
Clinical microbiology laboratories are faced with the challenge of accurate detection of emerging antibiotic resistance among several important gram positive bacterial pahtogens. For enterococci, vancomycin and ampicillin resistance was significantly more prevalent among E. faecium than among E. faecalis...
Con el descubrimiento de la vancomicina y con ella el surgimiento de la familia de los glicopéptidos se aumentó la eficacia en el tratamiento contra los gérmenes grampositivos, específicamente los stafilococos meticillino-resistentes. Fueron incrementándose a esta familia nuevos compuestos que reduj...
