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Characterisation of alternative expression vectors for recombinant Bacillus Calmette-Guérin as live bacterial delivery systems

Nascimento, Larissa V; Santos, Carina C; Leite, Luciana CC; Nascimento, Ivan P.
Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND Bacillus Calmette-Guérin (BCG) is considered a promising live bacterial delivery system. However, several proposals for rBCG vaccines have not progressed, mainly due to the limitations of the available expression systems. OBJECTIVES To obtain a set of mycobacterial vectors using a range of...
Vacuna BCG/inmunología, Escherichia coli/genética, Escherichia coli/inmunología, Vectores Genéticos/genética, Vectores Genéticos/inmunología, Proteínas Fluorescentes Verdes/inmunología, Ratones Endogámicos BALB C, Mycobacterium bovis/inmunología, Mycobacterium smegmatis/inmunología
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Stable expression of Mycobacterium bovis antigen 85B in auxotrophic M. bovis bacillus Calmette-Guérin

Rizzi, Caroline; Peiter, Ana Carolina; Oliveira, Thaís Larré; Seixas Neto, Amilton Clair Pinto; Leal, Karen Silva; Hartwig, Daiane Drawanz; Seixas, Fabiana Kommling; Borsuk, Sibele; Dellagostin, Odir Antônio.
Mem. Inst. Oswaldo Cruz; 112 (2), 2017
BACKGROUND Bovine tuberculosis (TB) is a zoonotic disease caused by Mycobacterium bovis, responsible for causing major losses in livestock. A cost effective alternative to control the disease could be herd vaccination. The bacillus Calmette-Guérin (BCG) vaccine has a limited efficacy against bovine TB,...
Antígenos Bacterianos/inmunología, Antígenos Bacterianos/metabolismo, Vacuna BCG/genética, Vacuna BCG/inmunología, Escherichia coli/genética, Vectores Genéticos, Vectores Genéticos/inmunología, Ratones Endogámicos BALB C, Mycobacterium bovis/genética, Mycobacterium bovis/inmunología, Plásmidos/genética, Plásmidos/inmunología
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