LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Improving adenoviral vectors and strategies for prostate cancer gene therapy

Tamura, Rodrigo Esaki; de Luna, Igor Vieira; Lana, Marlous Gomes; Strauss, Bryan E.

Clinics; 73 (supl.1), 2018

Gene therapy has been evaluated for the treatment of prostate cancer and includes the application of adenoviral vectors encoding a suicide gene or oncolytic adenoviruses that may be armed with a functional transgene. In parallel, versions of adenoviral vector expressing the p53 gene (Ad-p53) have been te...

Adenoviridae/genética, Carcinoma de Pulmón de Células no Pequeñas/genética, Genes Transgénicos Suicidas, Terapia Genética/métodos, Vectores Genéticos/uso terapéutico, Neoplasias Pulmonares/genética, Proteínas de Neoplasias/genética, Antígeno Prostático Específico/genética, Neoplasias de la Próstata/genética, Neoplasias de la Próstata/inmunología, Neoplasias de la Próstata/terapia, Proteína p53 Supresora de Tumor/biosíntesis

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Gene therapy: advances, challenges and perspectives

ABSTRACT The ability to make site-specific modifications to the human genome has been an objective in medicine since the recognition of the gene as the basic unit of heredity. Thus, gene therapy is understood as the ability of genetic improvement through the correction of altered (mutated) genes or site-...