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Recombinant antibodies against Iranian cobra venom as a new emerging therapy by phage display technology

Nazari, Ali; Samianifard, Maedeh; Rabie, Hadi; Mirakabadi, Abbas Zare.
J. venom. anim. toxins incl. trop. dis; 26 (), 2020
The production of antivenom from immunized animals is an established treatment for snakebites; however, antibody phage display technology may have the capacity to delivery results more quickly and with a better match to local need. Naja oxiana, the Iranian cobra, is a medically important species, respons...
Venenos Elapídicos/síntesis química, Anticuerpos, Antivenenos, Mordeduras de Serpientes, Técnicas In Vitro, Bacteriófagos/aislamiento & purificación
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BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation

Bezerra, Patrícia Heloise Alves; Ferreira, Isadora Marques; Franceschi, Beatriz Tinoco; Bianchini, Francine; Ambrósio, Luciana; Cintra, Adélia Cristina O; Sampaio, Suely Vilela; Castro, Fabíola Attié de; Torqueti, Maria Regina.
J. venom. anim. toxins incl. trop. dis; 25 (), 2019
Breast cancer is the neoplasm with both the highest incidence and mortality rate among women worldwide. Given the known snake venom cytotoxicity towards several tumor types, we evaluated the effects of BthTX-I from Bothrops jararacussu on MCF7, SKBR3, and MDAMB231 breast cancer cell lines. Methods: Bth...
Venenos Elapídicos/síntesis química, Bothrops, Neoplasias de la Mama, Células Madre Neoplásicas, Citometría de Flujo, Apoptosis
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