LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus

Caldas, Lúcio Ayres; Freitas, Tânia Rosária Pereira; Azevedo, Renata Campos; de Souza, Wanderley.

Braz. j. microbiol; 49 (4), 2018

ABSTRACT Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 µg/mL). Light and electron microscopy of infected cells shows t...

Antivirales/análisis, Antivirales/farmacología, Diarrea Mucosa Bovina Viral/tratamiento farmacológico, Diarrea Mucosa Bovina Viral/virología, Línea Celular, Diarrea, Virus de la Diarrea Viral Bovina/efectos de los fármacos, Virus de la Diarrea Viral Bovina/genética, Virus de la Diarrea Viral Bovina/fisiología, Prostaglandinas A/análisis, Prostaglandinas A/farmacología, Replicación Viral/efectos de los fármacos

Fulltext

Use of homologous recombination in yeast to create chimeric bovine viral diarrhea virus cDNA clones

Abstract The open reading frame of a Brazilian bovine viral diarrhea virus (BVDV) strain, IBSP4ncp, was recombined with the untranslated regions of the reference NADL strain by homologous recombination in Saccharomyces cerevisiae, resulting in chimeric full-length cDNA clones of BVDV (chi-NADL/IBSP4ncp#2...