Epilepsy is the chronic non-communicable disease of the nervous system most prevalent in the world. Valproic acid (VPA) is one of the most used drugs in the treatment of epilepsy but with various side effects. One of the organs that can be affected is the testis, where it has been seen that men treated w...
El ácido valproico (VPA) es un fármaco antiepiléptico teratógenico que, al ser administrado durante etapas tempranas del embarazo, puede producir alteraciones en el desarrollo embriofetal, las que se manifiestan tanto a nivel del sistema nervioso como del testículo. No obstante, se ha reportado que ...
SUMMARY: An association between certain food additives and chronic diseases is reported. Current study determined whether administering toxic doses of the food additive monosodium glutamate (MSG) into rats can induce aortopathy in association with the oxidative stress and inflammatory biomarkers upregula...
Aorta/efectos de los fármacos,
Vitamina E/farmacología,
Glutamato de Sodio/toxicidad,
Enfermedades de la Aorta/inducido químicamente,
Estrés Oxidativo/efectos de los fármacos,
Modelos Animales de Enfermedad,
Microscopía Electrónica,
Aorta/patología,
Vitamina E/administración & dosificación,
Glutamato de Sodio/administración & dosificación,
Ratas Sprague-Dawley,
Malondialdehído/antagonistas & inhibidores,
Interleucina-6/antagonistas & inhibidores,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
SUMMARY: In testicular differentiation, somatic cells must adopt a specific destiny towards sustentacular, peritubular and interstitial cells, being fundamental for the morphogenesis of seminiferous tubules, mediated by morphogens such as Desert Hedgehog (DHH), insulin-like growth factor-1 (IGF-1) and fi...
This experiment was designed to study the effects of oral administration of artemether which is the most rapid-acting class of antimalarial drugs and the possible protective effect of vitamin E taken with it on the liver of albino rats. A total of twenty-four adult male albino rats were used in this stud...
This experiment was designed to study the administration of normal doses of one of recent antimalarial drug and coadministration of vitamin E on the kidney tissue. A total twenty-four adult male albino rats were used and divided into four groups: the first one served as a control, the second received art...
Lesión Renal Aguda/inducido químicamente,
Vitamina E/farmacología,
Vitamina E/administración & dosificación,
Arteméter/toxicidad,
Biomarcadores/análisis,
Microscopía Electrónica,
Riñón/efectos de los fármacos,
Riñón/ultraestructura,
Riñón/patología,
Antimaláricos/toxicidad,
Ratas Wistar
Food additives and flavour enhancers used in the food industry are potential health risks. We tested the hypothesis that the food additive and flavour enhancer, monosodium glutamate (MSG), which is the sodium salt of glutamic acid can induce ultrastructural alterations to the kidney, and the antioxidant ...
Lesión Renal Aguda/inducido químicamente,
Lesión Renal Aguda/patología,
Vitamina E/uso terapéutico,
Vitamina E/farmacología,
Glutamato de Sodio/toxicidad,
Riñón/patología,
Ratas Sprague-Dawley,
Modelos Animales de Enfermedad,
Microscopía Electrónica de Transmisión,
Lesión Renal Aguda/tratamiento farmacológico,
Riñón/ultraestructura
SUMMARY: We sought to investigate the potential protective effect of Vitamin E supplementation against hepatocyte ultrastructural alterations induced by high fat diet (HFD) in a rat model of pre-diabetes. Therefore, rats were either fed with HFD (model group) or a standard laboratory chow (control group)...
Dieta Alta en Grasa/efectos adversos,
Estado Prediabético/tratamiento farmacológico,
Enfermedad del Hígado Graso no Alcohólico/prevención & control,
Hepatocitos/efectos de los fármacos,
Hepatocitos/ultraestructura,
Modelos Animales de Enfermedad,
Vitamina E/administración & dosificación,
Hígado/efectos de los fármacos,
Microscopía Electrónica de Transmisión,
Colesterol/análisis,
Alanina Transaminasa/efectos de los fármacos,
Aspartato Aminotransferasas/efectos de los fármacos,
Factor de Necrosis Tumoral alfa/efectos de los fármacos,
Malondialdehído/análisis,
Estrés Oxidativo/efectos de los fármacos,
Vitamina E/farmacología
Introdução: Considerando um número estimado de cerca de
51 milhões de cirurgias a cada ano apenas nos EUA, podemos
dizer que a hipertrofia cicatricial é um problema relevante,
já que uma cicatriz fina, de boa qualidade, pode ser a linha
divisória entre um bom resultado e uma cirurgia malsucedida.
...
Cicatriz Hipertrófica,
Cicatriz Hipertrófica/cirugía,
Cicatriz Hipertrófica/prevención & control,
Complicaciones Posoperatorias,
Complicaciones Posoperatorias/cirugía,
Hipertrofia,
Hipertrofia/cirugía,
Hipertrofia/terapia,
Heridas y Lesiones,
Heridas y Lesiones/cirugía,
Heridas y Lesiones/terapia,
Siliconas,
Siliconas/uso terapéutico,
Vitamina E,
Vitamina E/farmacología,
Vitamina E/uso terapéutico,
Literatura de Revisión como Asunto,
Estudios Prospectivos,
Estudio Clínico
BACKGROUND: Gossypol is a chemical present in the seeds of cotton plants (Gossypium sp.) that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious effects of free radicals. The aim of this study was to evaluate the mechanisms of ...
Anticonceptivos Masculinos/farmacología,
Fertilidad/efectos de los fármacos,
Gosipol/farmacología,
Vitamina E/farmacología,
Gosipol/efectos adversos,
Peroxidación de Lípido/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Espermatozoides/efectos de los fármacos,
Glutatión Peroxidasa,
Glutatión Reductasa,
Malondialdehído,
Ratas Wistar,
Testículo/efectos de los fármacos
