This article aimed to discuss the protection of trans
-
nerolidol on vascular endothelial cells
(ECs) injured by lipopolysac
charides. ECs were divided into four groups: normal, model, low and high
dose trans
-
nerolidol treatment groups. The cell survival rate and th...
SUMMARY: Hypoxic preconditioning is known to induce neuroprotection, but its effects and pathways in chronic brain pathology still unknown. The aim was to establish an involvement of a7 subunit of nicotinic acetylcholine receptors (a7nAchRs), and sirtuins of 1 (SIRT1) and 3 (SIRT3) types in the effects o...
SUMMARY: Overexpression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in various tumor tissues and cell lines was found to promote tumor cell proliferation, migration, and invasion. However, the role of MALAT1 in gastric cancer (GC) is still unclear. We aimed to investigate the corre...
Neoplasias Gástricas/patología,
ARN Largo no Codificante,
Proliferación Celular,
Factor A de Crecimiento Endotelial Vascular,
Serina-Treonina Quinasas TOR,
Transducción de Señal,
Neoplasias Gástricas/genética,
ARN/genética,
Western Blotting,
Genes Reporteros,
Invasividad Neoplásica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación Neoplásica de la Expresión Génica,
Movimiento Celular,
Apoptosis
SUMMARY: We evaluated the role and mechanism of acteoside in the regulation of memory impairment induced by chronic unpredictable mild stress (CUMS). CUMS was used to induce depression in rats and the successful establishment of CUMS model were verified by forced swimming test and sucrose preference test...
Estrés Psicológico/complicaciones,
Trastornos de la Memoria/tratamiento farmacológico,
Glucósidos/administración & dosificación,
Glucósidos/uso terapéutico,
Polifenoles/administración & dosificación,
Polifenoles/uso terapéutico,
Reconocimiento en Psicología/efectos de los fármacos,
Plasticidad Neuronal/efectos de los fármacos,
Serina-Treonina Quinasas TOR/antagonistas & inhibidores,
Depresión/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Ratas Sprague-Dawley,
Escala de Evaluación de la Conducta,
Neuronas,
Técnica del Anticuerpo Fluorescente,
Western Blotting,
Aprendizaje por Laberinto,
Inhibidores mTOR
SUMMARY: Senile osteoporosis is mainly caused by reduced osteoblast differentiation and has become the leading cause of fractures in the elderly worldwide. Natural organics are emerging as a potential option for the prevention and treatment of osteoporosis. This study was designed to study the effect of ...
Resveratrol/administración & dosificación,
Resveratrol/farmacología,
Osteoporosis/tratamiento farmacológico,
Diferenciación Celular/efectos de los fármacos,
Células Madre Mesenquimatosas/efectos de los fármacos,
Células Madre Mesenquimatosas/citología,
Sirtuina 1,
Modelos Animales de Enfermedad,
Western Blotting,
Ratones Endogámicos C57BL,
Osteogénesis/efectos de los fármacos
SUMMARY: Esophageal cancer is one of the most aggressive gastrointestinal cancers. Invasion and metastasis are the main causes of poor prognosis of esophageal cancer. SPRY2 has been reported to exert promoting effects in human cancers, which controls signal pathways including PI3K/AKT and MAPKs. However,...
A medula óssea é um compartimento complexo do corpo humano com funções cruciais para manutenção da fisiologia hematopoética, tendo componentes protagonistas como as células-tronco hematopoéticas (CTHs) que participam ativamente da produção dos fatores sanguíneos, e as células-tronco mesenqui...
Células Madre Mesenquimatosas/clasificación,
Citometría de Flujo/instrumentación,
d0185940,
Células Madre Hematopoyéticas/clasificación,
Daño del ADN/efectos de los fármacos,
Enfermedad/clasificación,
d0108270,
Neoplasias Hematológicas/prevención & control,
d0118780,
Técnicas de Cultivo de Célula/métodos,
Western Blotting/métodos
SUMMARY: Keloid scar is a unique benign fibroproliferative tumor of the human skin. Previously, it was reported that early growth response 1 (EGR1), a transcription factor, promotes keloid fibrosis; however, the mechanism by which EGR1 modulates keloid formation was not elaborated. In this research, the ...
Fibroblastos,
Queloide/patología,
Transfección,
Queloide/genética,
MicroARNs/fisiología,
Proteína 1 de la Respuesta de Crecimiento Precoz,
Apoptosis,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Western Blotting,
Proliferación Celular,
Movimiento Celular,
Regulación hacia Abajo,
d0347410,
Análisis de Secuencia de ARN,
Cicatrización de Heridas
SUMMARY: This study is to investigate the effect of survivin down-regulation by Egr1-survivin shRNA combined with radiotherapy on the apoptosis and radiosensitivity of esophageal squamous cell carcinoma ECA109 and KYSE150 cells. ECA109 and KYSE150 cells were transfected with Egr1-survivin shRNA, and then...
Neoplasias Esofágicas/terapia,
Carcinoma de Células Escamosas de Esófago/terapia,
Neoplasias Esofágicas/genética,
Carcinoma de Células Escamosas de Esófago/genética,
Transfección,
Survivin,
Fármacos Sensibilizantes a Radiaciones,
Neoplasias Esofágicas/radioterapia,
Carcinoma de Células Escamosas de Esófago/radioterapia,
Línea Celular Tumoral/efectos de la radiación,
ARN Mensajero,
Western Blotting,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación hacia Abajo,
Apoptosis,
Citometría de Flujo,
Caspasa 3,
Caspasa 9,
ARN Interferente Pequeño,
Terapia Combinada,
Tolerancia a Radiación,
Proteína 1 de la Respuesta de Crecimiento Precoz
SUMMARY: To evaluate the anti-cancer effects of yeast extract on resistant cells, autophagy and necroptosis were investigated in 5-fluorouracil (5-FU)-resistant colorectal cancer cells. Further underlying characteristics on drug resistance were evaluated, focused on ERK-RSK-ABCG2 linkage. SNU-C5 and 5-FU...
Extractos Vegetales/farmacología,
Neoplasias Colorrectales/tratamiento farmacológico,
Resistencia a Antineoplásicos,
Fluorouracilo,
Autofagia,
Antineoplásicos/farmacología,
Proteínas Quinasas S6 Ribosómicas 90-kDa,
Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2,
Células Tumorales Cultivadas,
Levaduras,
Necroptosis,
Supervivencia Celular/efectos de los fármacos,
Western Blotting,
Electroforesis
