Results: 2

Mannich bases derivatives of 2-Phenyl-5-Benzimidazole sulfonic acid; Synthesis, Characterization, Computational studies and Biological evaluation

Abstract A new series of N-Mannich bases of 2-Phenyl-5-benzimidazole sulfonic acid have been synthesized through amino methylation reaction with secondary amines. The two moieties were held together through a methylene bridge, which comes from formaldehyde (Formalin Solution 37%) used in the reaction. Ch...

Eficacia y seguridad del tratamiento con alglucosidasa alfa para pacientes adultos con forma tardía de enfermedad de Pompe

Tecnología: La droga alglucosidasa alfa reemplaza la enzima alfa‐glucosidasa ácida (GAA) deficitaria en la enfermedad de Pompe tardía y degradaría el glucógeno lisosomal. De este modo, la terapia de sustitución enzimática compensaría el déficit de GAA que causa la enfermedad d...