Long non-coding RNA HOTAIR promotes UVB-induced apoptosis and inflammatory injury by up-regulation of PKR in keratinocytes
Braz. j. med. biol. res; 51 (8), 2018
Excessive exposure to ultraviolet (UV) rays can cause damage of the skin and may induce cancer, immunosuppression, photoaging, and inflammation. The long non-coding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) is involved in multiple human biological processes. However, its role in UVB-induced kera...
Apoptosis/fisiología, Apoptosis/efectos de la radiación, Factor Inductor de la Apoptosis/metabolismo, Supervivencia Celular/fisiología, Expresión Génica, Inflamación/etiología, Interleucina-6/metabolismo, Queratinocitos/metabolismo, Queratinocitos/efectos de la radiación, FN-kappa B/efectos de los fármacos, FN-kappa B/metabolismo, Fosfatidilinositol 3-Quinasas/metabolismo, ARN Largo no Codificante/metabolismo, Factor de Necrosis Tumoral alfa/metabolismo, Rayos Ultravioleta/efectos adversos, Regulación hacia Arriba, eIF-2 Quinasa/metabolismo