Evolución de un linfoma no Hodgkin "triple expresor" en un paciente trasplantado renal con quimioterapia DA-R-EPOCH. Caso clínico
Triple expressor lymphoma in a kidney transplant patient
Rev. méd. Chile; 147 (2), 2019
Publication year: 2019
Patients transplanted from solid organs have an increased risk of cancer, especially lymphomas. Lymphomas correspond to 4 to 5% of malignant neoplasms in the general population and in solid organ transplant patients it reaches an incidence of 21%. The incidence of non-Hodgkin lymphomas is 10 times higher than in the non-transplanted population. We report the case of a 68-year-old man with a kidney transplant who 6 years after transplantation, developed a non-Hodgkin diffuse large cells B lymphoma with lymph node and pulmonary involvement, with markers of very poor prognosis (triple MYC expressor, BCL2 and BCL6). and its evolution with chemotherapy with DA R EPOCH.
Linfoma de Células B Grandes Difuso/genética, Linfoma no Hodgkin, Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico, Biomarcadores de Tumor/genética, Ciclofosfamida/uso terapéutico, Doxorrubicina/uso terapéutico, Etopósido/uso terapéutico, Genes myc/genética, Trasplante de Riñón/efectos adversos, Linfoma de Células B Grandes Difuso/tratamiento farmacológico, Linfoma de Células B Grandes Difuso/etiología, Linfoma no Hodgkin/tratamiento farmacológico, Linfoma no Hodgkin/etiología, Prednisona/uso terapéutico, Proteínas Proto-Oncogénicas c-bcl-6/genética, Proteínas Proto-Oncogénicas c-bcl-2/genética, Vincristina/uso terapéutico