The World Health Organization (WHO) defines health not only as the absence of disease but as a state of complete physical, mental and social well-being. Gratitude is one of the concepts most commonly associated with well-being from the empirical point of view. Despite of this, we seldom use the concept, possibly due to the lack of dissemination of its scientific bases and possible clinical applications. At an anatomical level, it is related consistently with the medial prefrontal cortex and at molecular level, with the neuropeptide oxytocin. It has been associated with better physical and mental health parameters, both in healthy and sick populations. It is usually measured using scales, being the most used worldwide the Gratitude Questionnaire-6 item (GQ-6). There are exercises that can enhance gratitude and its benefits, such as the gratitude letter and the gratitude journal. Given the current state of knowledge about gratitude, and considering its potential benefits, low risks, ability to complement other treatments, the simple and cost-effectiveness of gratitude interventions, a continuing research on this topic and its practical implementation is warranted.