This paper explains the elementary law of homeopathy, the Law of Similars, on the bases of thermodynamic aspects by means of the chemical thermodynamic. Le Chatelier principle was used, to explain the re-establishment of starting biochemical equilibrium compartmentalized in individual human cells of an ill person consuming the remedy, to clarify the Law of Similars. In addition, the application of the Law of mass action during the re-establishment of the initial equilibrium in an ill person when digesting the remedy exposed the law of Similars as the strongest outcome of homeopathy