Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region
Mem. Inst. Oswaldo Cruz; 114 (), 2019
Publication year: 2019
A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed.
The following resistance rates were observed:
penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C2611T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes).
Antibacterianos/farmacología, Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos, Farmacorresistencia Bacteriana Múltiple/genética, Pruebas de Sensibilidad Microbiana, Mutación, Neisseria gonorrhoeae/efectos de los fármacos, Neisseria gonorrhoeae/genética, Factores de Tiempo, Población Urbana