There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment

Silva, Paula Carolina Valença; Silva, Aline Vieira da; Silva, Taysa Nascimento; Vasconcelos, Letícia Moura de; Gomes, Adriana Vieira; Coêlho, Maria Rosângela Cunha Duarte; Muniz, Maria Tereza Cartaxo; Domingues, Ana Lúcia Coutinho

There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment

Silva, Paula Carolina Valença; Silva, Aline Vieira da; Silva, Taysa Nascimento; Vasconcelos, Letícia Moura de; Gomes, Adriana Vieira; Coêlho, Maria Rosângela Cunha Duarte; Muniz, Maria Tereza Cartaxo; Domingues, Ana Lúcia Coutinho.

Rev. Soc. Bras. Med. Trop; 49 (6), 2016

Publication year: 2016

Abstract INTRODUCTION:

We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis.

METHODS:

This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression.

RESULTS:

There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment.

CONCLUSIONS:

There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.

Interleucina-10/genética, Fibrosis Peritoneal/tratamiento farmacológico, Fibrosis Peritoneal/genética, Fibrosis Peritoneal/parasitología, Polimorfismo Genético, Estudios Retrospectivos, Esquistosomiasis mansoni/complicaciones, Índice de Severidad de la Enfermedad

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