Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
Rev. Soc. Bras. Med. Trop; 50 (5), 2017
Publication year: 2017
Abstract INTRODUCTION:
Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets.METHODS:
The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry.RESULTS:
Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease.CONCLUSIONS:
These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.
Linfocitos T CD4-Positivos/química, Linfocitos T CD8-positivos/química, Cardiomiopatía Chagásica/sangre, Cardiomiopatía Chagásica/patología, Citometría de Flujo, Expresión Génica, Persona de Mediana Edad, Fenotipo, Receptores CCR/sangre, Valores de Referencia, Índice de Severidad de la Enfermedad, Estadísticas no Paramétricas