Abstract INTRODUCTION:

Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection.

METHODS:

Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial.

RESULTS:

Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels.

CONCLUSIONS:

BCG responsiveness does not affect protection against atopy.