The relationship between atopy and neurological manifestations in HTLV-1 infection
Rev. Soc. Bras. Med. Trop; 51 (2), 2018
Publication year: 2018
Abstract INTRODUCTION:
Human T-cell lymphotropic virus type 1 (HTLV-1)induces exaggerated Th1 responses, whereas atopy is associated with exacerbated Th2 responses.METHODS:
Here, a cross-sectional study compared the prevalence of atopy in HTLV-1 carriers and HAM/TSP patients. It also compared the spontaneous cytokine production in HTLV-1-infected individuals. A retrospective cohort study evaluated the development of neurological manifestations in atopic and non-atopic carriers.RESULTS:
Atopic HAM/TSP patients with high IFN-γ production exhibited higher IL-5 levels than non-atopic patients. Allergic rhinitis accelerated the development of Babinski signals and overactive bladders.CONCLUSIONS:
Abnormal Th1 and Th2 responses coexist in HTLV-1-infected individuals and allergic diseases may worsen the clinical course of HTLV-1 infections.
Estudios de Cohortes, Estudios Transversales, Citocinas/biosíntesis, Infecciones por HTLV-I/complicaciones, Infecciones por HTLV-I/inmunología, Infecciones por HTLV-I/patología, Hipersensibilidad Inmediata/sangre, Hipersensibilidad Inmediata/epidemiología, Hipersensibilidad Inmediata/inmunología, Persona de Mediana Edad, Enfermedades del Sistema Nervioso/inmunología, Enfermedades del Sistema Nervioso/virología, Paraparesia Espástica Tropical/complicaciones, Paraparesia Espástica Tropical/inmunología, Paraparesia Espástica Tropical/patología, Estudios Retrospectivos