Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice

Fernandes, Erica de Souza; Lorena, Virgínia Maria de Barros; Sales, Iana Rafaela Fernandes; Albuquerque, Mônica Camelo Pessoa de Azevedo; Gomes, Yara de Miranda; Costa, Vlaudia Maria Assis; Souza, Valdênia Maria Oliveira de

Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice

Fernandes, Erica de Souza; Lorena, Virgínia Maria de Barros; Sales, Iana Rafaela Fernandes; Albuquerque, Mônica Camelo Pessoa de Azevedo; Gomes, Yara de Miranda; Costa, Vlaudia Maria Assis; Souza, Valdênia Maria Oliveira de.

Rev. Soc. Bras. Med. Trop; 51 (4), 2018

Publication year: 2018

Abstract INTRODUCTION:

We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers.

METHODS:

We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry.

RESULTS:

BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells.

CONCLUSIONS:

Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.

Animales Lactantes/inmunología, Animales Lactantes/parasitología, Anticuerpos Antihelmínticos/inmunología, Citometría de Flujo, Interleucina-10/inmunología, Interleucina-2/inmunología, Ratones, Ovalbúmina/inmunología, Esquistosomiasis mansoni/inmunología, Linfocitos T Reguladores/inmunología

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