Biofilm formation by blood isolates of candida parapsilosis sensu stricto in the presence of a hyperglycidic solution at comparable concentrations of total parenteral nutrition

Herek, Thalita Caroline; Menegazzo, Vinícius Ribeiro; Ogaki, Mayara Baptistucci; Perini, Hugo Felix; Maia, Luciana Furlaneto; Furlaneto, Marcia Cristina

Biofilm formation by blood isolates of candida parapsilosis sensu stricto in the presence of a hyperglycidic solution at comparable concentrations of total parenteral nutrition

Herek, Thalita Caroline; Menegazzo, Vinícius Ribeiro; Ogaki, Mayara Baptistucci; Perini, Hugo Felix; Maia, Luciana Furlaneto; Furlaneto, Marcia Cristina.

Rev. Soc. Bras. Med. Trop; 52 (), 2019

Publication year: 2019

Abstract INTRODUCTION:

Administration of total parenteral nutrition (TPN) via catheters increases the risk for candidemia from Candida parapsilosis.

METHODS:

C. parapsilosis sensu stricto blood isolates were evaluated for ability total biomass biofilm formation and morphogenesis in presence of glucose at TPN equivalent concentrations.

RESULTS:

Biofilms were increased at high glucose concentrations (25-30%) compared to the control medium. Significant increase in filamentous forms was observed in cultures with 30% glucose.

CONCLUSIONS:

Biofilm formation by C. parapsilosis sensu stricto in hyperglycidic medium may contribute to its pathogenic potential for fungemia related to TPN catheters.

Biopelículas/efectos de los fármacos, Biopelículas/crecimiento & desarrollo, Candida parapsilosis/fisiología, Recuento de Colonia Microbiana, Medios de Cultivo/química, Glucosa/farmacología, Nutrición Parenteral Total en el Domicilio

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