Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients
Rev. Soc. Bras. Med. Trop; 52 (), 2019
Publication year: 2019
Abstract INTRODUCTION:
Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria.METHODS:
This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study.RESULTS:
Some cases of QT prolongation were observed. However, no TdP was found.CONCLUSIONS:
AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.
Antimaláricos/efectos adversos, Antimaláricos/uso terapéutico, Artemisininas/efectos adversos, Artemisininas/uso terapéutico, Quimioterapia Combinada, Electrocardiografía, Síndrome de QT Prolongado/inducido químicamente, Síndrome de QT Prolongado/diagnóstico, Malaria Falciparum/tratamiento farmacológico, Persona de Mediana Edad, Quinolinas/efectos adversos, Quinolinas/uso terapéutico, Estudios Retrospectivos