Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria
Rev. Soc. Bras. Med. Trop; 52 (), 2019
Publication year: 2019
Abstract INTRODUCTION:
Plant products are sources for drug development against multidrug resistant bacteria. METHODS The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays. RESULTS Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment. CONCLUSIONS OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.
Acinetobacter baumannii/efectos de los fármacos, Acinetobacter baumannii/crecimiento & desarrollo, Antibacterianos/clasificación, Antibacterianos/farmacología, Proteínas Bacterianas, Carbapenémicos/farmacología, Farmacorresistencia Bacteriana Múltiple, Bacterias Gramnegativas/efectos de los fármacos, Bacterias Gramnegativas/crecimiento & desarrollo, Klebsiella pneumoniae/efectos de los fármacos, Klebsiella pneumoniae/crecimiento & desarrollo, Pruebas de Sensibilidad Microbiana, Aceites Volátiles/farmacología, Origanum/química, Serratia marcescens/efectos de los fármacos, Serratia marcescens/crecimiento & desarrollo, beta-Lactamasas