HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C
Rev. Soc. Bras. Med. Trop; 52 (), 2019
Publication year: 2019
Abstract INTRODUCTION:
HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC.METHODS:
PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients.RESULTS:
There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree.CONCLUSIONS:
The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence.
Antígenos de Plaqueta Humana/genética, Carcinoma Hepatocelular/genética, Carcinoma Hepatocelular/virología, Progresión de la Enfermedad, Marcadores Genéticos, Genotipo, Hepatitis C Crónica/genética, Hepatitis C Crónica/virología, Neoplasias Hepáticas/genética, Neoplasias Hepáticas/virología, Persona de Mediana Edad, Reacción en Cadena de la Polimerasa, Pronóstico, Factores de Riesgo