Abstract INTRODUCTION:

Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival.

METHODS:

Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host.

RESULTS:

Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture.

CONCLUSIONS:

These findings highlight the role of host stress in the virulence of S. epidermidis.