This study was interested in exploring, through a mixed design, the relationship between the quality of life, well-being and caregiver burden in two regions of Colombia.

87 caregivers participated in the quantitative component respond three scales:

Zarit´s burden caregiver Scale, the WHOQOL-BREF quality of life scale and the subjective Wellbeing test. The groups of regions (Andean and Caribean) were compared using the student t- test for independent samples because these variables showed normal distribution. There were significant differences between well-being (t= -1.79) and caregiver burden(t=0.84). The differences between regions in quality of life was measured by U-Mann-Whitney test, due to its asymmetric distribution, finding that there are no differences in the domains of quality of life that include: physical health, psychological health, relationships and the environment. In the qualitative component, 24 caregivers participated in focus groups. The qualitative results were worked through thematic analysis of the discourse. The qualitative results showed that there is little family support in both regions, stress and constant frustration, economic difficulties and with health institutions. The discussion is focus on the difficulties in handling emotions during their daily work and high levels of overload in the studied population are discussed to indicate the relevance of psychological support.