Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil
Rev. Soc. Bras. Med. Trop; 53 (), 2020
Publication year: 2020
Abstract INTRODUCTION:
Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs).METHODS:
Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital.RESULTS:
The key genes found were bla OXA-51-like, the association ISAba1- bla OXA-23-like, and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards.CONCLUSIONS:
The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.
Infecciones por Acinetobacter/microbiología, Acinetobacter baumannii/efectos de los fármacos, Acinetobacter baumannii/enzimología, Acinetobacter baumannii/aislamiento & purificación, Aminoglicósidos/genética, Antibacterianos/farmacología, Proteínas Bacterianas/genética, Brasil, Farmacorresistencia Bacteriana Múltiple, Unidades de Cuidados Intensivos, Pruebas de Sensibilidad Microbiana, Centros de Atención Terciaria, beta-Lactamasas/genética