Aim/Case report: We have described here the diagnosis and treatment of two cases involving atypical mucosal lesions originating from primary endodontic infections in young patients. Differential diagnoses were established by clinical and radiographic examinations. In both the cases, a red-colored lesion was observed in the alveolar mucosa, with a soft consistency and a sessile-base without any drainage path in tooth 31 (case 1) and with a sinus tract in tooth 36 (case 2), as confirmed by X-ray. The cleaning and shaping of the root canals were performed, and camphorated paramonochlorofenol (CPMC)-enriched calcium hydroxide paste was used as an intracanal dressing for 6 months, with replacement every 60 days.

Conclusion:

Based on our experience, we thus conclude that long-term root canal maintenance with CPMC-enriched calcium hydroxide was an effective therapeutic protocol for promoting the healing of atypical mucosal lesions