Adverse drug events and the associated factors in patients with chronic Chagas disease

Lopes, Luiza Braz da Cunha; Pereira, Raquel Rodrigues; Andrade, Patricia Mello; Carneiro, Fernanda Martins; Mediano, Mauro Felippe Felix; Kilgore, Sophia Isabel Linnemann; Hasslocher-Moreno, Alejandro Marcel; Sousa, Andréa Silvestre de; Oliveira, Manoel Marques Evangelista; Saraiva, Roberto Magalhães; Holanda, Marcelo Teixeira de; Silva, Gilberto Marcelo Sperandio da

Adverse drug events and the associated factors in patients with chronic Chagas disease

Lopes, Luiza Braz da Cunha; Pereira, Raquel Rodrigues; Andrade, Patricia Mello; Carneiro, Fernanda Martins; Mediano, Mauro Felippe Felix; Kilgore, Sophia Isabel Linnemann; Hasslocher-Moreno, Alejandro Marcel; Sousa, Andréa Silvestre de; Oliveira, Manoel Marques Evangelista; Saraiva, Roberto Magalhães; Holanda, Marcelo Teixeira de; Silva, Gilberto Marcelo Sperandio da.

Rev. Soc. Bras. Med. Trop; 53 (), 2020

Publication year: 2020

Abstract INTRODUCTION:

Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients.

METHODS:

We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs.

RESULTS:

ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs.

CONCLUSIONS:

Close follow-up is warranted for CD patients.

Algoritmos, Brasil/epidemiología, Enfermedad de Chagas/tratamiento farmacológico, Enfermedad Crónica, Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/epidemiología, Persona de Mediana Edad, Índice de Severidad de la Enfermedad, Factores Socioeconómicos

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