Clinical cases treated with appliances commonly known as aligners are presented, proving that changes take place in all spatial directions and make it possible to carry out complete treatment without resorting to other resources than sequenced thermoformed plates. These ones are made following progressive setups developed in the digital flow. Pros and cons of the management of the new treatment mechanics are analyzed, emphasizing the adherence to the following protocol: diagnosis, prognosis, list of issues, objectives stating, treatment plan making, stages diagramming, renders visualization to make sure of the necessary movements, their sequence according to a new paradigm of individual and controlled threedimensionally movement, communication with and achievement of patient’s maximum cooperation, accurate follow-up of expected actions, application of attachments, programmed wear, clinical change control according to the number of aligner/render number, achievement of the stated objectives, occlusal controls performance, fulfilment of a retention strategy and subsequent rehabilitation if necessary(AU)