Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine

Helito, Alberto C.; Lindoso, Livia; Sieczkowska, Sofia M.; Astley, Camilla; Queiroz, Ligia B.; Rose, Natalia; Santos, Claudia Renata P.; Bolzan, Thalis; Peralta, Rita María I.A.; Franco, Ruth R.; Cominato, Louise; Pereira, Rosa Maria R.; Tannuri, Uenis; Campos, Lucia Maria A.; Lourenço, Benito; Toma, Ricardo K.; Medeiros, Karina; Watanabe, Andréia; Grangeiro, Patricia Moreno; Farhat, Sylvia C.; Casella, Caio B.; Polanczyk, Guilherme V.; Gualano, Bruno; Silva, Clovis A.; Sallum, Adriana M. E.; Iraha, Amanda Y.; Ihara, Bianca P.; Mazzolani, Bruna C.; Martinez, Claudia A.; Strabelli, Claudia A. A.; Fonseca, Claudia B.; Lima, Dandara C. C.; Setoue, Debora N. D.; Roz, Deborah F. P.; Smaira, Fabiana I.; Roschel, Hamilton; Miyatani, Helena T.; Marques, Isabela G.; Oba, Jane; Ferreira, Juliana C. O.; Simon, Juliana R.; Kozu, Katia; Saccani, Ligia P.; Martiniano, Lorena V. M.; Miranda, Luana C. A.; Silva, Luiz E. V.; Laurentino, Moisés F.; Aikawa, Nadia E.; Sakita, Neusa K.; Tanigava, Nicolas Y.; Pereira, Paulo R. A.; Palmeira, Patrícia; Angelo, Simone S.; Lavorato, Sofia S. M.; Bernardes, Tamires M.; Franco, Tathiane C.; Viana, Vivianne S. L.; Barros, Vera P. M. F. R.; Zheng, Yingying

Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine

Helito, Alberto C.; Lindoso, Livia; Sieczkowska, Sofia M.; Astley, Camilla; Queiroz, Ligia B.; Rose, Natalia; Santos, Claudia Renata P.; Bolzan, Thalis; Peralta, Rita María I.A.; Franco, Ruth R.; Cominato, Louise; Pereira, Rosa Maria R.; Tannuri, Uenis; Campos, Lucia Maria A.; Lourenço, Benito; Toma, Ricardo K.; Medeiros, Karina; Watanabe, Andréia; Grangeiro, Patricia Moreno; Farhat, Sylvia C.; Casella, Caio B.; Polanczyk, Guilherme V.; Gualano, Bruno; Silva, Clovis A.; Sallum, Adriana M. E.; Iraha, Amanda Y.; Ihara, Bianca P.; Mazzolani, Bruna C.; Martinez, Claudia A.; Strabelli, Claudia A. A.; Fonseca, Claudia B.; Lima, Dandara C. C.; Setoue, Debora N. D.; Roz, Deborah F. P.; Smaira, Fabiana I.; Roschel, Hamilton; Miyatani, Helena T.; Marques, Isabela G.; Oba, Jane; Ferreira, Juliana C. O.; Simon, Juliana R.; Kozu, Katia; Saccani, Ligia P.; Martiniano, Lorena V. M.; Miranda, Luana C. A.; Silva, Luiz E. V.; Laurentino, Moisés F.; Aikawa, Nadia E.; Sakita, Neusa K.; Tanigava, Nicolas Y.; Pereira, Paulo R. A.; Palmeira, Patrícia; Angelo, Simone S.; Lavorato, Sofia S. M.; Bernardes, Tamires M.; Franco, Tathiane C.; Viana, Vivianne S. L.; Barros, Vera P. M. F. R.; Zheng, Yingying.

Clinics; 76 (), 2021

Publication year: 2021

OBJECTIVE:

To assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during the coronavirus disease 2019 (COVID-19) pandemic.

METHODS:

This cross-sectional study included 305 adolescents with chronic immunocompromised conditions and 82 healthy adolescents. Online surveys were completed, which included questions on socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and the following validated questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), and Pediatric Outcome Data Collection Instrument (PODCI).

RESULTS:

The median current age [14 (10-18) vs. 15 (10-18) years, p=0.847] and frequency of female sex (62% vs. 58%, p=0.571) were similar in adolescents with chronic conditions compared with healthy adolescents. The frequency of poor sleep quality was similar in both groups (38% vs. 48%, p=0.118). Logistic regression analysis, including both healthy adolescents and adolescents with chronic conditions (n=387), demonstrated that self-reported increase in screen time (odds ratio [OR] 3.0; 95% confidence interval [CI] 1.3-6.8; p=0.008) and intrafamilial violence report (OR 2.1; 95% CI 1.2-3.5; p=0.008) were independently associated with poor sleep quality in these adolescents. However, the PODCI global function score was associated with a lower OR for poor sleep quality (OR 0.97; 95% CI 0.94-0.99; p=0.001). Further logistic regression, including only adolescents with chronic conditions (n=305), demonstrated that self-reported increase in screen time (OR 3.1; 95% CI 1.4-6.8; p=0.006) and intrafamilial violence report (OR 2.0; 95% CI 1.2-3.4; p=0.011) remained independently associated with poor quality of sleep, whereas a lower PODCI global function score was associated with a lower OR for sleep quality (OR 0.96; 95% CI 0.94-0.98; p<0.001).

CONCLUSION:

Self-reported increases in screen time and intrafamilial violence report impacted sleep quality in both healthy adolescents and those with chronic conditions. Decreased health-related quality of life was observed in adolescents with poor sleep quality.

COVID-19, Enfermedad Crónica, Estudios Transversales, Calidad de Vida, Cuarentena, SARS-CoV-2, Sueño, Encuestas y Cuestionarios

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