Lifestyle, psychological well-being, and body mass index of indigenous women. Introduction. Obesity is more common in women and has also been found to be present in indigenous populations. During university studies, obesity-related lifestyles are in the process of consolidation, and although this is known, research is limited to addressing physical activity and diet, ignoring other lifestyle components, such as life appreciation. Additionally, there is a need to corroborate whether psychological well-being contributes to excess weight in indigenous women. Objective. To determine whether there is an association between lifestyle, psychological well-being, and body mass index (BMI) in indigenous women. Materials and methods. A cross-sectional study was conducted among 110 female Zapotec university students in Juchitán, Oaxaca, Mexico. The Psychological Well-Being Scale, the Healthy Lifestyle Scale for University Students, and a questionnaire about personal data were used. Body weight and height were measured to calculate BMI. Results. There was a negative correlation between BMI, self-acceptance (r = -0.33; p < 0.01), and life appreciation (r = -0.22; p < 0.05). Positive correlations were found between lifestyle and psychological well-being dimensions, with the strongest correlations being observed between life appreciation and purpose in life (r = 0.55) and self-acceptance (r = 0.48). The multivariable models determined that life appreciation and self-acceptance are associated with BMI. Conclusion. Life appreciation and self-acceptance are predictors of BMI and are even more strongly associated than exercise and nutrition behaviors(AU)