Adverse effects associated with favipiravir in patients with COVID-19 pneumonia: a retrospective study
Säo Paulo med. j; 140 (3), 2022
Publication year: 2022
ABSTRACT BACKGROUND:
Favipiravir is generally used in treating coronavirus disease 2019 (COVID-19) pneumonia in Turkey.OBJECTIVE:
To determine the side effects of favipiravir and whether it is a good treatment option.DESIGN AND SETTING:
Retrospective study conducted in Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.METHODS:
357 patients who completed favipiravir treatment at the recommended dose were included. 37 patients with drug side effects and 320 patients without drug side effects were examined in two groups.RESULTS:
Side effects were observed in 37 (10.36%) out of 357 patients using favipiravir. The most common side effect was liver dysfunction, in 26 (7.28%) of the patients.The following other side effects were also observed:
diarrhea (1.4%), nausea (0.84%), abdominal pain (0.28%) and thrombocytopenia (0.28%). One patient (0.28%) presented both increased transaminases and nausea.CONCLUSION:
In this study, it was determined that favipiravir may constitute an alternative for treating COVID-19 pneumonia given that its side effects are generally well tolerated and not serious.
Amidas, Antivirales/efectos adversos, COVID-19/tratamiento farmacológico, Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/tratamiento farmacológico, Náusea/inducido químicamente, Náusea/tratamiento farmacológico, Pirazinas, Estudios Retrospectivos, SARS-CoV-2, Resultado del Tratamiento