Human bite wounds are less common than those caused by animal bites, and in general are contaminated by a wider range of microorganisms, thus increasing incidence of infectious complications. Patient management in the emergency room consists in aesthetic and functional rehabilitation and infection prevention. The aim of this article is to report a case of human bite to the face with upper lip and oral commissure tissue loss of a patient, who was a victim of assault, seen at a public emergency hospital in Rio de Janeiro, providing information on the clinical characteristics of the injury and the most appropriate treatment for the case studied.